Physcion Induces Hemolysis and Premature Phosphatidylserine Externalization in Human Erythrocytes
نویسندگان
چکیده
منابع مشابه
Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin
The opportunistic pathogen Pseudomonas aeruginosa causes a wide range of infections in multiple hosts by releasing an arsenal of virulence factors such as pyocyanin. Despite numerous reports on the pleiotropic cellular targets of pyocyanin toxicity in vivo, its impact on erythrocytes remains elusive. Erythrocytes undergo an apoptosis-like cell death called eryptosis which is characterized by ce...
متن کاملCaspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes.
The appearance of phosphatidylserine (PS) on the outer surface of red cells is an important signal for their uptake by macrophages. We report for the first time that procaspase 3 present in the anucleated mature human erythrocyte is activated under oxidative stress induced by t-butylhydroperoxide leading to impairment of the aminophospholipid translocase, PS externalization and increased erythr...
متن کاملLysophosphatidic acid induces thrombogenic activity through phosphatidylserine exposure and procoagulant microvesicle generation in human erythrocytes.
OBJECTIVE Although erythrocytes have been suggested to play a role in blood clotting, mediated through phosphatidylserine (PS) exposure and/or PS-bearing microvesicle generation, an endogenous substance that triggers the membrane alterations leading to a procoagulant activity in erythrocytes has not been reported. We now demonstrated that lysophosphatidic acid (LPA), an important lipid mediator...
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The cluster Re6Se8I63- has been shown to induce preferential cell death of a hepatic carcinoma cell line, thus becoming a promising anti-cancer drug. Whether this cluster induces acute hemolysis or if it interacts with albumin remains unclear. The effect of acute exposure of human red blood cells to different concentrations of the cluster with and without albumin is described. Red blood cells f...
متن کاملPhosphatidylserine transport in Rhnull erythrocytes.
Phosphatidylserine transport in normal and Rhnull red blood cells was determined by measuring characteristic morphologic changes induced by synthetic phospholipids. Treating normal A+ cells with commercial anti-A antisera, anti-Rho(D) antisera, or with saturating concentrations of purified Rho(D) antibodies had no effect on phosphatidylserine transport. Normal B- cells treated with purified ant...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2021
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b20-00744